THC and CBD both are the natural compounds that are easily found in the cannabis plant. No doubt that the chemical composition of both Tetrahydrocannabinol and Cannabidiol is different but to see a simple difference, THC is known as psychoactive, while CBD is not psychoactive. However, to understand the clear difference between THC and CBD, you need to read this article for better understanding.

THC Vs CBD-What is the main difference?

There are almost 113 cannabinoids which have been found till now, in which the THC and CBD are well known. To understand the main difference between THC and CBD, we first discuss the plant genus of them.

Plant Genus

As we know cannabis plants are from the family of plant types, which include marijuana and hemp which are two different things. It is also considered as THC compound is responsible for getting a person high when using marijuana as it derives from marijuana. While CBD has the medical effects and is derived from the hemp plant. But these two compounds are totally different in their working. Marijuana is knowns for its medical effects and hemp is widely known for its industrial uses.

Psychoactive Vs. Non-Psychoactive

One of the main difference between CBD and THC is the effect of two types; euphoric and high when consumed.


THC works directly as an agonist of the endocannabinoid system’s cannabinoid 1 receptors (CB1) located in the central and peripheral nervous system. CBD works directly as an agonist of the endocannabinoid system’s cannabinoid 2 receptors (CB2) only expressed in immune tissues.
THC is considered as the component which is responsible for the mind-altering effects. On the other hand, CBD doesn’t bind with receptors CB1 and that’s why doesn’t have mind-altering effects.
It changes the functionality of brain which leads to the high. CBD is known for many  physiological effects that promote and maintain health

To demonstrate the more clear difference and comparison of THC Vs CBD, let’s discuss the basic definition of them.

What is CBD?

Cannabidiol or CBD is one of the many chemical products under the class called cannabinoids. It naturally occurs in cannabis plants. However, due to its capacity to deliver a high level of mental and physical benefits without titters, paranoia, it is one of the famous compounds. The main factor that makes CBD different from THC is it don’t case any psychoactive side effects or any mind-altering side effects.

What is THC?

Tetrahydrocannabinol is another chemical compound that is famous for its strong cerebral euphoria effects. It also lies under the same class of cannabinoids and naturally occurs in cannabis plants. However, it is different from THC due to its psychoactive effects.

THC VS CBD-How both work

No doubt that both of the compounds have their own distinctive properties and functioning in the body, but both works to compensate the human brain and immune system.

How do CBD works?

The working of CBD is different from THC. The CBD interacts with the cannabinoid receptors; CB1 and CB2 receptors which are found in endocannabinoid system. However, endocannabinoids activate both types of receptors in the body. The main endocannabinoids that are found in the body are anandamide and arachidonoyl glycerol (2-AG). While CBD doesn’t act directly on cannabinoid receptors, rather it works indirectly on them and also boosts the endocannabinoids levels in the body. On the other side, CBD also accelerates the endocannabinoids release and interferes with the natural breakdown.

With the advancement, now the pure forms of CBD also come in the form of CBD oil, capsules, etc.

How do THC works?

The working of THC is quite different from CBD, it penetrates the brains by stimulating the cells and allow them to release a substance called dopamine. Moreover, it also works to activate receptors which affect the functioning of the brain. In the initial stage, the brain will be relaxed and other sensors will be enhanced. Some other effects include a mixture of various emotions such as happiness, anxiety and pain relief. Moreover, it also causes delusions.

Natural Sources

While talking about the natural sources of both THC and CBD are as follows:

THC is naturally found in Cannabis Plants which include Indica, Sativa and also Ruderalis. However, a small amount of THC is also found in Hemp.

While talking about the natural sources for CBD, then it is mainly found in both types of plants; cannabis and industrial hemp.

What are the effects of CBD and THC?

Anti-depressant: It acts as anti-depressant and help in the fight against anxiety and depression.

Anti-oxidant: It aids in the fight against neuro-degenerative disorders.

Neuro-protective: It helps to protect neurons in the brain.

Anti-emetic: It helps to reduce vomiting and nausea.

Anti-tumoral: It battles against cancerous cells and tumor.

Analgesic: CBD helps in relief from pain and inflammation.

Relaxation: It helps to create the feeling of relaxation and well-being.

Drowsiness: CBD is best to reduce sleep.

Appetite stimulant: Perfect to create an urge to eat.

Euphoria: It promotes the state of ‘High’

Medical applications of THC

There are many medical applications of THC which include fighting against pain, sleep, nausea, and stress disorders, etc.

Similarly, it also helps in the fight against chemotherapy, glaucoma, AIDS and spinal injuries.

Medical applications of CBD

If you want to win fight against, stress, cancer, anxiety, depression, inflammation, epilepsy, migraines, schizophrenia, and arthritis, then CBD is the best choice.

Why is CBD considered over THC?

THC no doubt is an illegal drug in most parts of the world due to its long-term cognitive side effects. These side effects include reducing thinking and ability to play, decision making, etc. Moreover, it also causes many abnormalities in the brain and the heart.

On the hand other, CBD has low health risks as it counteracts the psychoactive effects of THC, also it lacks all these harmful and dangerous cognitive effects which are features by THC. That is why people love to consider the most popular form of CBD-CBD oil for health benefits.